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Our in vitro results advise that EAM-2201 ought to be examined concerning prospective in vivo pharmacokinetic drug–drug interactions caused by time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 routines and aggressive inhibition of UGT1A3 exercise.
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Our in vitro outcomes propose that EAM-2201 really should be examined regarding potential in vivo pharmacokinetic drug–drug interactions attributable to time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 functions and competitive inhibition of UGT1A3 action.
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Then, the inhibitor concentration that supports half the maximal rate of inhibition (Ki) and maximal charge of enzyme inhibition (kinact) values ended up calculated applying the subsequent equation with Enzyme Kinetics software program:
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